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KMID : 0368019890120030223
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Journal of Soonchunhyang University
1989 Volume.12 No. 3 p.223 ~ p.229
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2years; Experience of Chorionic Villus Sampling
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차상헌/Cha, Sang-hun
이임순/조태호/유훈/Lee, Im Soon/Cho, Tae ho/Yoo Hoon
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Abstract
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Chonionic villus samping for the first trimester prenatal diagnosis has the potential of becoming an attractive alternative to midtrimester amniocentesis. Prior to becoming a standard, however, considerable caution and monitoring is necessary to establish the accuracy and safety of the procedure. In this pursuit, we wish to present our experience and trial in the technical aspects and safety of chorionicvillus samping. Chorionic villi were obtained by transcervical catheter(Trophocan and S-1) or transabdominal 19 gauge spinal needle under the real-time ultrasound guidance. Both direct and cultivation method of chorionic villus for chromosome preparation were performed.
The patients consisted of 135 pregnant women who did genetic chorionic sampling in 8 to 14 weeks gestation with genetic indications
The results obtained were as followes:
1) The chromosomal abnormality was found in 7 cases(5.2%): 1 in 47, XX, +21, 2 in 46, XY, inv(9)(pllq 21), 1 in 15q partial trisomy, 2 in 47, XXY and 1 in 45, X / 47, XXX.
2) The fetal loss was found in 4 cases(3.0%).
These results suggest that chorionic villus sampling now be considered a vialbe and quite possibly and equal safe alternative to second trimester amniocentesis.
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